プレMAF
提携機関／産学連携
Pre-MAF therapy An order-made treatment associated with minimal adverse reactions that uses glycoproteins purified from autologous serum
- Pre-MAF purification Patent No. 5701587
- Pre-MAF purification Patent No. 5860401
Toppage- Pre-MAF therapy
What is pre-MAF?
What is pre-MAF therapy that uses autologous serum glycoproteins (pre-MAF)?
Cancer immunotherapy utilizing two patented technologies
Pre-MAF therapy is a treatment method that utilizes one's own glycoproteins to enhance the function of innate immunity and respond to diseases such as cancer. Since this therapy is customized for each patient, it is made to order for each individual. The "pre-MAF" glycoprotein used in pre-MAF therapy is purified to a purity of at least 90% from at least 100 types of glycoproteins contained in serum using two patented technologies* developed by Morita.
* Patent No. 5701587 (Proteins that specifically bind to vitamin D-binding proteins)/Patent No. 5860401 (Method for producing a novel galactose deglycosylated form of Gc globulins)
Four features
01
Improves immune function
The immune system is a system in which various cells work in conjunction to protect the body against foreign substances. One of the cells that plays an important role is the macrophage. Macrophages also exhibit a strong phagocytic (direct ingestion) effect, and they have been shown to cooperate with other immune system cells to eliminate foreign substances by presenting the characteristics of the phagocytosed foreign substances to other immune system cells. Cancer impairs the innate immune system, and the aim of pre-MAF therapy is to boost the immune system by activating macrophages through the administration of a glycoprotein (precursor) "pre-MAF."
02
Fewer adverse reactions
Since this therapy is produced on an individualized basis using the patient's own serum, treatment is associated with fewer adverse reactions and can be administered with minimal physical strain on the patient.
03
Can be combined with other therapies
This therapy can be indicated for all patients. Since components produced by the body are utilized, this therapy is unlikely to interfere with other therapies and can be used in combination.
04
Less expensive than other immunotherapies
We are making efforts to reduce the cost of this therapy so that it can be easily combined with other treatments, thereby reducing the financial burden on patients.
Treatment concept
By enhancing the function of one's own innate immune system through macrophage activation and inhibiting the supply of oxygen and nutrients through the inhibition of angiogenesis, inhibiting the growth of cancer cells is thought to be feasible.
- When the immune system is functioning properly…
- The "pre-MAF" glycoprotein activates macrophages in the body through a two-step reaction. Macrophages work in conjunction with other immune cells to eliminate foreign substances that enter the body.
- When the immune system is not functioning properly…
- However, the first stage of the reaction in the body is known to possibly not proceed smoothly due to cancer cells and a variety of other factors. This results in macrophages, which play a crucial role in the immune system, becoming inactive, leading to a weakened immune response.
- Administration of purified pre-MAF
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Activating macrophages, even in an immunosuppressed state
The "pre-MAF" glycoprotein activates macrophages in the body through a two-step reaction. Macrophages work in conjunction with other immune cells to eliminate foreign substances that enter the body.
Flow of treatment
Pre-MAF is administered subcutaneously once a week, with one treatment course consisting of 10 injections. This process will take approximately 3.5 months, from blood collection/serum extraction to the completion of administration.
